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A polyaxonal amacrine cell population in the primate retina.

Greschner, Martin Field, Greg D Li, Peter H Schiff, Max L Gauthier, Jeffrey L Ahn, Daniel Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, populations of PACs were identified by their distinctive radially propagating spikes in large-scale high-density multielectrode ...

Restoration of retinal structure and function after selective photocoagulation.

Sher, Alexander Jones, Bryan W Huie, Philip Paulus, Yannis M Lavinsky, Daniel Leung, Loh-Shan S Nomoto, Hiroyuki Beier, Corinne Marc, Robert E Palanker, Daniel ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivit...

Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucl...

Shanks, James A Ito, Shinya Schaevitz, Laura Yamada, Jena Chen, Bin Litke, Alan Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The dorsal lateral geniculate nucleus (dLGN) is a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in the retina, and feed back inputs from layer 6 neurons in the visual cortex. In this study we examined genetically manipulated mice that develop without a cortex or without cortical layer 6 axonal proje...

The structure of large-scale synchronized firing in primate retina.

Shlens, Jonathon Field, Greg D Gauthier, Jeffrey L Greschner, Martin Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Synchronized firing among neurons has been proposed to constitute an elementary aspect of the neural code in sensory and motor systems. However, it remains unclear how synchronized firing affects the large-scale patterns of activity and redundancy of visual signals in a complete population of neurons. We recorded simultaneously from hundreds of ret...

A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro.

Tang, Aonan Jackson, David Hobbs, Jon Chen, Wei Smith, Jodi L Patel, Hema Prieto, Anita Petrusca, Dumitru Grivich, Matthew I Sher, Alexander ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al., 2006; Shlens et al., 2006...

Spatially patterned electrical stimulation to enhance resolution of retinal prostheses.

Jepson, Lauren H Hottowy, Paweł Mathieson, Keith Gunning, Deborah E Dąbrowski, Władysław Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Retinal prostheses electrically stimulate neurons to produce artificial vision in people blinded by photoreceptor degenerative diseases. The limited spatial resolution of current devices results in indiscriminate stimulation of interleaved cells of different types, precluding veridical reproduction of natural activity patterns in the retinal output...

Efficient coding of spatial information in the primate retina.

Doi, Eizaburo Gauthier, Jeffrey L Field, Greg D Shlens, Jonathon Sher, Alexander Greschner, Martin Machado, Timothy A Jepson, Lauren H Mathieson, Keith Gunning, Deborah E ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties of the visual system have been found consistent with human perception, but they have not been compared directly with neural ...

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