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Deep Brain Stimulation for Tourette Syndrome: Target Selection PDF available through Get Fulltext Research

Viswanathan, Ashwin Jimenez-Shahed, Joohi Baizabal Carvallo, José Fidel Jankovic, Joseph

Published in Stereotactic and Functional Neurosurgery

Background/Aims: Tourette syndrome (TS) is a complex neurological disorder manifested chiefly by motor and phonic tics and a variety of behavioral comorbidities, including attention disorder, obsessive-compulsive disorder and impulse control problems. Surgical treatment is increasingly considered when tics become troublesome or even disabling or se...

Spatially patterned electrical stimulation to enhance resolution of retinal prostheses.

Jepson, Lauren H Hottowy, Paweł Mathieson, Keith Gunning, Deborah E Dąbrowski, Władysław Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Retinal prostheses electrically stimulate neurons to produce artificial vision in people blinded by photoreceptor degenerative diseases. The limited spatial resolution of current devices results in indiscriminate stimulation of interleaved cells of different types, precluding veridical reproduction of natural activity patterns in the retinal output...

A polyaxonal amacrine cell population in the primate retina.

Greschner, Martin Field, Greg D Li, Peter H Schiff, Max L Gauthier, Jeffrey L Ahn, Daniel Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, populations of PACs were identified by their distinctive radially propagating spikes in large-scale high-density multielectrode ...

Compartmental genomics in living cells revealed by single-cell nanobiopsy.

Actis, Paolo Maalouf, Michelle M Kim, Hyunsung John Lohith, Akshar Vilozny, Boaz Seger, R Adam Pourmand, Nader

Published in ACS nano

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual ce...

Retinal representation of the elementary visual signal. PDF available through Get Fulltext Research

Li, Peter H Field, Greg D Greschner, Martin Ahn, Daniel Gunning, Deborah E Mathieson, Keith Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in Neuron

The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong respo...

DIALIGN-TX: greedy and progressive approaches for segment-based multiple sequence alignment PDF available through Get Fulltext Research

Subramanian, Amarendran R Kaufmann, Michael Morgenstern, Burkhard

Published in Algorithms for Molecular Biology

BackgroundDIALIGN-T is a reimplementation of the multiple-alignment program DIALIGN. Due to several algorithmic improvements, it produces significantly better alignments on locally and globally related sequence sets than previous versions of DIALIGN. However, like the original implementation of the program, DIALIGN-T uses a a straight-forward greed...

Current status and new features of the Consensus Coding Sequence database. PDF available through Get Fulltext Research

Farrell, Catherine M O'Leary, Nuala A Harte, Rachel A Loveland, Jane E Wilming, Laurens G Wallin, Craig Diekhans, Mark Barrell, Daniel Searle, Stephen M J Aken, Bronwen ...

Published in Nucleic acids research

The Consensus Coding Sequence (CCDS) project (http://www.ncbi.nlm.nih.gov/CCDS/) is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies by the National Center for Biotechnology Information (NCBI) and Ensembl genome annotation pipelines. Identical an...

The somatic genomic landscape of glioblastoma. PDF available through Get Fulltext Research

Brennan, Cameron W Verhaak, Roel G W McKenna, Aaron Campos, Benito Noushmehr, Houtan Salama, Sofie R Zheng, Siyuan Chakravarty, Debyani Sanborn, J Zachary Berman, Samuel H ...

Published in Cell

We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated m...

Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.

Vilozny, Boaz Wollenberg, Alexander L Actis, Paolo Hwang, Daniel Singaram, Bakthan Pourmand, Nader

Published in Nanoscale

Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic ac...

Integrative annotation of variants from 1092 humans: application to cancer genomics.

Khurana, Ekta Fu, Yao Colonna, Vincenza Mu, Xinmeng Jasmine Kang, Hyun Min Lappalainen, Tuuli Sboner, Andrea Lochovsky, Lucas Chen, Jieming Harmanci, Arif ...

Published in Science (New York, N.Y.)

Interpreting variants, especially noncoding ones, in the increasing number of personal genomes is challenging. We used patterns of polymorphisms in functionally annotated regions in 1092 humans to identify deleterious variants; then we experimentally validated candidates. We analyzed both coding and noncoding regions, with the former corroborating ...

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