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News 571 Publications 15 Members

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang

Published in Cellular Physiology and Biochemistry

Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...

Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucl...

Shanks, James A Ito, Shinya Schaevitz, Laura Yamada, Jena Chen, Bin Litke, Alan Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The dorsal lateral geniculate nucleus (dLGN) is a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in the retina, and feed back inputs from layer 6 neurons in the visual cortex. In this study we examined genetically manipulated mice that develop without a cortex or without cortical layer 6 axonal proje...

Facilitating a culture of responsible and effective sharing of cancer genome data.

Siu, Lillian L Lawler, Mark Haussler, David Knoppers, Bartha Maria Lewin, Jeremy Vis, Daniel J Liao, Rachel G Andre, Fabrice Banks, Ian Barrett, J Carl ...

Published in Nature medicine

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precisi...

UCSC Data Integrator and Variant Annotation Integrator.

Hinrichs, Angie S Raney, Brian J Speir, Matthew L Rhead, Brooke Casper, Jonathan Karolchik, Donna Kuhn, Robert M Rosenbloom, Kate R Zweig, Ann S Haussler, David ...

Published in Bioinformatics (Oxford, England)

Two new tools on the UCSC Genome Browser web site provide improved ways of combining information from multiple datasets, optionally including the user's own custom track data and/or data from track hubs. The Data Integrator combines columns from multiple data tracks, showing all items from the first track along with overlapping items from the other...

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1....

Khan, Shahid Y Vasanth, Shivakumar Kabir, Firoz Gottsch, John D Khan, Arif O Chaerkady, Raghothama Lee, Mei-Chong W Leitch, Carmen C Ma, Zhiwei Laux, Julie ...

Published in Nature communications

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified ...

Agarose- and alginate-based biopolymers for sample preparation: Excellent green extraction tools for this century.

Sanagi, Mohd Marsin Loh, Saw Hong Wan Ibrahim, Wan Nazihah Pourmand, Neda Salisu, Ahmed Wan Ibrahim, Wan Aini Ali, Imran

Published in Journal of separation science

Recently, there has been considerable interest in the use of miniaturized sample preparation techniques before the chromatographic monitoring of the analytes in unknown complex compositions. The use of biopolymer-based sorbents in solid-phase microextraction techniques has achieved a good reputation. A great variety of polysaccharides can be extrac...

Fitting Frequency-Lowering Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guidelin...

Scollie, Susan Glista, Danielle Seto, Julie Dunn, Andrea Schuett, Brittany Hawkins, Marianne Pourmand, Nazanin Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying technologies can supplement such guidelines. One such technology is frequency-lowering signal processing. Children require access to a broad bandwidth of speech to detect and use all phonemes i...

Fitting Noise Management Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guideline:...

Scollie, Susan Levy, Charla Pourmand, Nazanin Abbasalipour, Parvaneh Bagatto, Marlene Richert, Frances Moodie, Shane Crukley, Jeff Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying some technologies are not always available. One such technology is noise management in children's hearing aids. Children are frequently in high-level and/or noisy environments, and many options...

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells.

Franco, Magdalena Panas, Michael W Marino, Nicole D Lee, Mei-Chong Wendy Buchholz, Kerry R Kelly, Felice D Bednarski, Jeffrey J Sleckman, Barry P Pourmand, Nader Boothroyd, John C ...

Published in mBio

The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc-GFP), we isolated mutant tachyzoites defectiv...

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