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Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes PDF available through Get Fulltext Research

Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang

Published in Cellular Physiology and Biochemistry

Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...

Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucl...

Shanks, James A Ito, Shinya Schaevitz, Laura Yamada, Jena Chen, Bin Litke, Alan Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The dorsal lateral geniculate nucleus (dLGN) is a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in the retina, and feed back inputs from layer 6 neurons in the visual cortex. In this study we examined genetically manipulated mice that develop without a cortex or without cortical layer 6 axonal proje...

Facilitating a culture of responsible and effective sharing of cancer genome data.

Siu, Lillian L Lawler, Mark Haussler, David Knoppers, Bartha Maria Lewin, Jeremy Vis, Daniel J Liao, Rachel G Andre, Fabrice Banks, Ian Barrett, J Carl ...

Published in Nature medicine

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precisi...

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.... PDF available through Get Fulltext Research

Khan, Shahid Y Vasanth, Shivakumar Kabir, Firoz Gottsch, John D Khan, Arif O Chaerkady, Raghothama Lee, Mei-Chong W Leitch, Carmen C Ma, Zhiwei Laux, Julie ...

Published in Nature communications

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified ...

Agarose- and alginate-based biopolymers for sample preparation: Excellent green extraction tools for this century.

Sanagi, Mohd Marsin Loh, Saw Hong Wan Ibrahim, Wan Nazihah Pourmand, Neda Salisu, Ahmed Wan Ibrahim, Wan Aini Ali, Imran

Published in Journal of separation science

Recently, there has been considerable interest in the use of miniaturized sample preparation techniques before the chromatographic monitoring of the analytes in unknown complex compositions. The use of biopolymer-based sorbents in solid-phase microextraction techniques has achieved a good reputation. A great variety of polysaccharides can be extrac...

Fitting Frequency-Lowering Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guidelin...

Scollie, Susan Glista, Danielle Seto, Julie Dunn, Andrea Schuett, Brittany Hawkins, Marianne Pourmand, Nazanin Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying technologies can supplement such guidelines. One such technology is frequency-lowering signal processing. Children require access to a broad bandwidth of speech to detect and use all phonemes i...

Fitting Noise Management Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guideline:...

Scollie, Susan Levy, Charla Pourmand, Nazanin Abbasalipour, Parvaneh Bagatto, Marlene Richert, Frances Moodie, Shane Crukley, Jeff Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying some technologies are not always available. One such technology is noise management in children's hearing aids. Children are frequently in high-level and/or noisy environments, and many options...

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. PDF available through Get Fulltext Research

Franco, Magdalena Panas, Michael W Marino, Nicole D Lee, Mei-Chong Wendy Buchholz, Kerry R Kelly, Felice D Bednarski, Jeffrey J Sleckman, Barry P Pourmand, Nader Boothroyd, John C ...

Published in mBio

The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc-GFP), we isolated mutant tachyzoites defectiv...

Contrast Sensitivity With a Subretinal Prosthesis and Implications for Efficient Delivery of Visual Information. PDF available through Get Fulltext Research

Goetz, Georges Smith, Richard Lei, Xin Galambos, Ludwig Kamins, Theodore Mathieson, Keith Sher, Alexander Palanker, Daniel

Published in Investigative ophthalmology & visual science

To evaluate the contrast sensitivity of a degenerate retina stimulated by a photovoltaic subretinal prosthesis, and assess the impact of low contrast sensitivity on transmission of visual information. We measure ex vivo the full-field contrast sensitivity of healthy rat retina stimulated with white light, and the contrast sensitivity of degenerate ...

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